Evaluating Moldable Matrix Materials: What to Review About BiFORM®

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BiFORM® Bioactive Moldable Matrix is a bioactive, osteoconductive bone graft offered by Sanara MedTech. After hydration, it can retain its strip form or be molded into a putty to fit a bone defect. This flexibility gives surgical teams different handling options when evaluating materials for an appropriate bone grafting application.

Selecting a moldable matrix involves more than comparing texture or ease of placement. Healthcare professionals also need to understand composition, labeled indications, preparation requirements, supporting evidence, and patient considerations. This guide explains BiFORM’s characteristics and the questions that can help teams conduct a focused product review.

Start With the Material’s Composition

Sanara identifies three components in BiFORM Bioactive Moldable Matrix:

50% carbonate apatite anorganic bone mineral
30% 45S5 bioactive glass
20% Type I collagen

The company describes a proprietary manufacturing process that distributes the bioactive glass and mineral particles throughout the matrix.

Sanara’s published research description identifies the anorganic bone mineral and Type I collagen as bovine-derived components.

Understanding these ingredients helps reviewers distinguish BiFORM from human allograft matrices and other bone graft materials. Composition also informs patient screening and discussions about material selection.

A useful comparison should examine the complete product. Materials containing collagen or mineral components can differ in their formulation, processing, handling, and intended use.

Understand Its Intended Role

BiFORM’s instructions describe use with autogenous bone marrow or autograft with saline for bony voids or gaps that are not intrinsic to the stability of the bony structure. It may also be used with autograft as a bone graft extender.

These details are central to evaluation. A team should begin with a clearly defined application and determine whether it aligns with the current instructions supplied with the product.

For example, reviewing a material to fill a contained bone void requires different questions from evaluating an implant intended to provide structural support. Defining the clinical need first helps reviewers assess relevant features without treating all bone graft products as interchangeable.

Distinguish Osteoconductivity From Structural Support

Sanara describes BiFORM as osteoconductive. Its instructions also state that the material does not provide sufficient mechanical strength to support a defect and is not indicated for load-bearing applications. Appropriate stabilization remains necessary.

This distinction matters when discussing what the product contributes to a surgical plan. A bone graft matrix’s biological role and a fixation system’s mechanical role require separate evaluation.

Surgical teams should identify how stability will be achieved and maintained before selecting a graft material. Moldability should not be interpreted as mechanical strength, and the ability to fill a defect does not establish that a material can bear functional loads.

Evaluate Strip and Putty Handling Options

BiFORM can be used as a hydrated strip or molded into alternative shapes. Sanara also describes a puck configuration suited to molding. These options allow clinicians to evaluate how the material accommodates different defect contours.

Handling questions should connect directly to the proposed application. Does the team need a material that retains a defined shape? Is conformability a priority? Which configuration and volume would best fit the planned workflow?

Product education can help staff understand those options before clinical use. A structured review should also consider how preparation affects consistency and how the surgeon intends to place and contain the material.

Review Hydration and Preparation Requirements

Sanara’s product page describes hydration options and use with autogenous bone marrow or autograft. The detailed preparation method should follow the applicable instructions for use.

For facilities, preparation is both a clinical and operational consideration. Teams can identify which supplies must be available, who will prepare the matrix, and where staff can access the instructions.

The package insert directs users to avoid overfilling or compressing the treatment site.

An implementation discussion should therefore cover more than achieving a moldable texture. It should address preparation, placement, and the requirements of the intended procedure.

Put Irrigation Resistance in Context

Sanara describes BiFORM as flexible, absorbent, and resistant to migration upon irrigation.

This handling characteristic gives surgical teams another feature to review. It does not remove the need to evaluate containment, stabilization, and placement.

When discussing irrigation resistance, reviewers can ask which supporting information is available and how the feature relates to their proposed technique. Keeping the discussion specific helps avoid interpreting a handling claim as unrestricted performance under every irrigation pressure or procedural condition.

Examine the Supporting Research

Sanara has published a description of a rabbit posterolateral spinal fusion study involving 36 animals. The study evaluated BiFORM combined with bone marrow aspirate or autograft and compared those groups with other graft approaches. Assessments occurred at four, eight, and fourteen weeks.

This research provides preclinical information. It should be assessed according to its animal model, treatment combinations, comparison groups, and measured outcomes.

Animal findings do not establish an equivalent human fusion rate or healing timeline. Teams evaluating BiFORM can ask what clinical evidence is available for their intended application and distinguish that evidence from laboratory or animal research.

Include Patient Selection in the Review

BiFORM’s instructions list contraindications that include infected sites, osteomyelitis at the operative site, and specified allergy histories, including known bovine collagen allergy. The full contraindications and precautions require review before use.

Patient selection should be part of the evaluation from the beginning. A product’s handling advantages do not determine whether it is suitable for an individual patient.

Facilities can incorporate current labeling into staff education and clinical review processes. This helps ensure that composition, intended use, and patient factors receive attention alongside practical product features.

Confirm Storage and Purchasing Requirements

BiFORM is supplied sterile for single use. Its listed storage range is 15–30°C.

Supply teams should confirm available configurations, sizes, ordering details, and expiration dates. A practical plan can assign responsibility for storage monitoring and product availability.

At Sanara MedTech, we help healthcare professionals access information about our surgical product portfolio.