How to Improve Nasolabial Folds Appearance with Hyaluronic Acid Dermal Fillers

By Your Health Magazine

Nasolabial folds, also known as melolabial creases, run from the nose down to the corners of the mouth. As skin loses elasticity and fat pads in the midface shift, the lines become more defined. These folds are part of normal anatomy, yet for many people, they are one of the first visible signs of aging.

Surgical lifting can reduce folds, but most people prefer less invasive care. In everyday practice, the most common method is injection with hyaluronic acid dermal fillers. Juvederm, Restylane, and Stylage fillers are one of the most effective options. Licensed specialists often obtain them through Cosmo Direct Supply, a safe dermal filler supplier that provides only authentic, as well as FDA-approved, dermal fillers.

Hyaluronic Acid and Its Role

Hyaluronic acid (HA) is present in the skin’s connective tissue and plays a role in hydration and firmness. As production slows with age, the skin loses support, and folds appear deeper. Injectable HA-based dermal fillers help restore hydration and improve overall midface area appearance. HA is biocompatible and naturally degradable, which explains why most FDA-approved dermal fillers use it as their main component.

The fold itself runs along the line where the cheek meets the upper lip. Its depth changes as fat pads in the midface shift and the skin loses natural support. With less collagen and elasticity, the crease gradually looks more defined.

Clinical Approach and Patient Safety

The purpose of treatment is to soften folds while keeping normal facial dynamics. Achieving this requires not only the right product but also an accurate technique. Too much filler can make the fold look heavy. Too little may not have visible effects. The treatment is not done in pregnancy, while breastfeeding, or if there is an infection or an allergy. Small bruises or swelling are common and usually clear in a few days.

Stylage: Mannitol and Injection Control

Stylage fillers combine cross-linked HA with mannitol, an antioxidant. Mannitol slows HA breakdown, helps limit swelling, and supports smoother recovery. The line includes several formulations. Stylage M and L are used for moderate folds, while XL and XXL provide stronger correction when volume loss is greater.

Depending on the formulation and the patient, the benefits may continue for about nine months to a year and a half. Stylage also employs the BI-SOFT syringe system, designed to give practitioners better control and more accurate placement.

Juvederm: Cohesivity and Longevity

Juvederm fillers are produced with Vycross® Technology, which links HA chains of different sizes. This process creates smooth gels that adapt well to tissue and are less prone to early breakdown. For nasolabial folds, Juvederm Ultra 3 is often used in moderate cases, while Ultra 4 is applied in deeper creases.

Volift generally shows good results for around 15 months, while Volux may keep improvements visible for close to two years, making it one of the most durable choices. Many Juvederm products also contain lidocaine, improving comfort during injection. Contraindications are the same as for other HA fillers.

Restylane: Clinical Record and Versatile Options

Restylane was the first HA filler approved by the FDA and has been in use since the 1990s. Two technologies define the line: NASHA®, producing firmer gels for lift, and XpresHAn®, creating softer fillers that move with expression. For treating folds, Restylane Lyft is often chosen for deeper lines. Defyne and Refyne combine support with flexibility, while Restylane Volyme restores midface volume, which indirectly helps reduce fold depth.

Depending on the product and individual metabolism, results may last anywhere from six months to a year and a half. Side effects are mild and temporary. Therapists and clinics purchase Restylane fillers through Cosmo Direct Supply, which guarantees an authentic supply.

Comparing the Brands

Stylage fillers, Juvederm fillers, and Restylane fillers are all hyaluronic acid dermal fillers, but they differ in design and clinical use. Stylage adds mannitol, which may reduce swelling and extend the effect. Juvederm is made with Vycross® Technology, which gives the gel a smooth texture and, in some cases, helps the results stay for nearly two years. Restylane has been used the longest and comes in both firm and flexible types, so healthcare professionals can adapt the choice to each patient.

A recent U.S. study from 2025 reviewed the use of resilient HA fillers for nasolabial folds. It found steady results across different skin types, with improvements lasting for about 15 months and a safety profile similar to other HA fillers already in use.

Choice is guided by rhytid severity, patient goals, and current physiological state. Sometimes, products are combined for a more tailored result.

Aftercare

Most people see changes right after the injection. For some patients, the improvement lasts only a few months, while others notice benefits for almost two years. The procedure itself is brief, and patients usually return to their routines the same day.

The duration of the results varies — filler type matters, but lifestyle and metabolism play their role as well. To support recovery, clinicians often recommend avoiding intense exercise, heat, or direct sun for a short time.

Importance of Authentic Supply

Authenticity is central to treatment safety. Counterfeit or poorly stored fillers can increase complications and reduce predictability. Clinics, therefore, work only with a safe dermal filler supplier. Cosmo Direct Supply provides Juvederm, Restylane, and Stylage, ensuring genuine, FDA-approved dermal fillers are always available.

Key Takeaways

Nasolabial folds are often among the first lines that stand out as the face ages. Dermal fillers offer a practical way to soften them, giving results that are both reliable and safe. Each brand brings something of its own — one supports recovery with antioxidants, another is built for longer-lasting effect, and a third has a record of use that spans decades.

For patients, the outcome is wrinkles that look less pronounced and healthy skin that feels more balanced. For practitioners, the focus stays on working with suppliers they can trust, so every treatment is done with products that are genuine and safe.

Practical Checklist for Patients and Practitioners

Before Treatment

Identify treatment goals: softening folds, restoring balance, or adding support.
Review contraindications: pregnancy, breastfeeding, allergies, or active infections.
Choose a clinic that works with a safe dermal filler supplier such as Cosmo Direct Supply.

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